Associations of smoking and plasma homocysteine level with main cardiac-cerebral vascular events in male patients with hypertension

QIU Mingjing; ZHANG Qi; JIN Aiping; WANG Wenxie; FANG Min; TAN Yan; LIU Xueyuan

doi:10.12022/jnnr.2016-0057

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Journal of Neurology and Neurorehabilitation ›› 2016, Vol. 12 ›› Issue (4) : 186-190. DOI: 10.12022/jnnr.2016-0057

Associations of smoking and plasma homocysteine level with main cardiac-cerebral vascular events in male patients with hypertension

QIU Mingjing, ZHANG Qi, JIN Aiping, WANG Wenxie, FANG Min, TAN Yan, LIU Xueyuan

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Abstract

Objective: To investigate the relationships between smoking and plasma homocysteine (Hcy) level with main cardiac-cerebral vascular events (MCCVEs) in male patients with hypertension.Methods: Three hundred and fifty-five male patients with hypertension were recruited in this study and divided into smoking group (n = 166) and non-smoking group (n = 189). The information of clinical records was collected. The plasma Hcy level was detected by velocity method. The relationships between smoking and plasma Hcy level with MCCVEs in male patients with hypertension were evaluated. The risk factors related to MCCVEs were examined using logistic regression analysis.Results: Plasma Hcy level in smoking group [(17.74±12.64) μmol/L] was higher than that in non-smoking group [(15.37±5.37) μmol/L] (P < 0.05). The incidence rate of MCCVEs in smoking group (57.83%) was higher than that in non-smoking group (44.44%) (χ² = 9.324, P < 0.05). Logistic regression analysis showed that age, course of hypertension, smoking and plasma Hcy level were independent risk factors of MCCVEs (all P < 0.05). The odds ratio of smoking was 1.786 (95% confidence interval: 1.131-2.820) and the odds ratio of plasma Hcy level was 1.035 (95% confidence interval: 1.004-1.073).Conclusion: Smoking is associated with increased level of plasma Hcy and higher incidence rate of MCCVEs in patients with hypertension. The age, course of hypertension, smoking and plasma Hcy level are independent risk factors of MCCVEs.

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Hypertension / Smoking / Homocysteine / Cardiac-cerebral vascular events

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QIU Mingjing, ZHANG Qi, JIN Aiping, WANG Wenxie, FANG Min, TAN Yan, LIU Xueyuan. Associations of smoking and plasma homocysteine level with main cardiac-cerebral vascular events in male patients with hypertension[J]. Journal of Neurology and Neurorehabilitation. 2016, 12(4): 186-190 https://doi.org/10.12022/jnnr.2016-0057

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