Poststroke depression (PSD) is the most common emotional disorder after stroke. PSD is one of the factors affecting the quality of life of stroke patients, which can affect the recovery of daily living ability and nerve function impairment, and cause the protracted course of stroke. The pathophysiological mechanism of PSD has not been fully elucidated, and may involve biological, behavioral and social factors. This paper reviews the pathogenesis, diagnosis and treatment of PSD.