Research progress in transcranial magnetic stimulation for the treatment of multiple system atrophy

LI Wanting , BAI Jing , BAI Ya , LI Xiaobing , MU Yaqian , LIU Xuedong

Journal of Neurology and Neurorehabilitation ›› 2026, Vol. 22 ›› Issue (3) : 20260008.

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Journal of Neurology and Neurorehabilitation ›› 2026, Vol. 22 ›› Issue (3) : 20260008. DOI: 10.12022/jnnr.2025-0242
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Research progress in transcranial magnetic stimulation for the treatment of multiple system atrophy

  • LI Wanting1 , BAI Jing2 , BAI Ya2 , LI Xiaobing2 , MU Yaqian2 , LIU Xuedong2
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Abstract

Multiple system atrophy (MSA) is a rare disease with an extremely poor prognosis, for which no effective treatment currently exists. In recent years, non-invasive neuromodulation techniques have shown significant advantages in the field of neurodegenerative diseases. Transcranial magnetic stimulation (TMS), as a non-invasive neuromodulation technique, has demonstrated potential in the treatment of various neurological disorders. This article aims to review the latest research progress on TMS for MSA, with a particular focus on the evidence of its efficacy against core motor symptoms (such as parkinsonism and ataxia) and some non-motor symptoms in MSA patients. The feasibility of broadly implementing TMS in the clinical management of MSA is also discussed.

Key words

Multiple system atrophy / Transcranial magnetic stimulation / Atypical parkinsonian syndrome / Non-invasive neuromodulation technique / Rehabilitation therapy

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LI Wanting , BAI Jing , BAI Ya , LI Xiaobing , MU Yaqian , LIU Xuedong. Research progress in transcranial magnetic stimulation for the treatment of multiple system atrophy[J]. Journal of Neurology and Neurorehabilitation. 2026, 22(3): 20260008 https://doi.org/10.12022/jnnr.2025-0242

Funding

1. Clinical Research Funding Program of Air Force Medical University (2022LC2216)
2. 2024 Clinical Research Special Fund for Medical Staff Development, First Affiliated Hospital of Air Force Medical University (XJZT24LY22)
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