The intertwined somatic damage and psychological distress induced by malignant tumors severely compromise patient prognosis. Currently, the construction of psychological intervention models in oncology that both meet modern evidence-based requirements and align with local cultural contexts has become an important endeavor in integrative oncology. The Huangdi Neijing states: "When the body and the spirit are united, they will live to the end of their allotted life span." This passage offers a profound articulation of the fundamental unity between the body and the mind—a conception that resonates closely with modern psychosomatic medicine and the neurobiological mechanisms underlying brain-body interactions. Centering on the concept of "integrated treatment of body and mind," this paper systematically reviews the pathological evolution of cancer-related emotional dysregulation from both Chinese and western medical perspectives, as well as the syndrome differentiation framework of "Five Zang-organs Storing Spirit". Drawing on an integrative medicine outlook, it further explores the organic interface between traditional Chinese medicine clinical pathways and the modern stepped-care model. Through a systematic exposition of non-pharmacological interventions—including Chinese psychological therapies, five-element music therapy, acupuncture, and auricular vagus nerve stimulation—alongside contemporary psychotherapeutic techniques, this paper constructs an integrated Chinese-western intervention strategy spanning the full disease continuum of cancer: from diagnosis and active treatment through rehabilitation and palliative care. The aim is to offer a new integrative therapeutic paradigm with distinctive Chinese characteristics for the advancement of modern psycho-oncology.