脑血管储备能力在缺血性卒中中的作用及研究进展

杨　雪; 王　雁

doi:10.12022/jnnr.2017-0054

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神经病学与神经康复学杂志 ›› 2017, Vol. 13 ›› Issue (4) : 213-220. DOI: 10.12022/jnnr.2017-0054

综述

脑血管储备能力在缺血性卒中中的作用及研究进展

杨　雪，王　雁

作者信息 +

The role of cerebrovascular reserve in ischemic stroke and its research progress

YANG Xue, WANG Yan

Author information +

文章历史 +

摘要

缺血性卒中发生时，为了满足代谢需要，脑血管具有自动调节血流量的能力，以对抗脑灌注压急性和慢性变化时对大脑的损伤，这种生理机制——脑血管储备能力（cerebrovascular reserve，CVR）往往可以帮助大脑度过危机。CVR是缺血性卒中病理生理研究领域的里程碑。然而，由于目前对CVR的认识尚不充分，因此限制了将CVR进一步作为缺血性卒中治疗的常规参考指标。本文对CVR的定义及生理机制、评估与干预以及临床应用的进展进行综述。

Abstract

Cerebral blood vessel has the ability to automatically adjust the blood flow to the brain and against the damage of acute or chronic cerebral perfusion pressure alteration to meet the needs of brain metabolism during the occurrence of ischemic stroke. Through this physiological mechanism which is named as cerebrovascular reserve (CVR), the brain can get through the crisis. As a milestone of the research in the pathophysiology of ischemic stroke, however, CVR has not been widely recognized, which restricts the clinical application of CVR in further use as a routine reference index for the treatment of ischemic stroke. In this paper, the definition of CVR and its physiological mechanism, evaluation and intervention, and the progress in clinical application are systematically reviewed.

导出引用

杨　雪，王　雁. 脑血管储备能力在缺血性卒中中的作用及研究进展[J]. 神经病学与神经康复学杂志. 2017, 13(4): 213-220 https://doi.org/10.12022/jnnr.2017-0054

YANG Xue, WANG Yan. The role of cerebrovascular reserve in ischemic stroke and its research progress[J]. Journal of Neurology and Neurorehabilitation. 2017, 13(4): 213-220 https://doi.org/10.12022/jnnr.2017-0054

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