脑卒中后抑郁（poststroke depression，PSD）是脑卒中后最常见的情绪障碍。PSD 会影响患者日常生活能力和神经功能缺损的恢复，造成脑卒中病程迁延，是影响脑卒中后患者生活质量的因素之一。PSD 的病理生理机制尚未完全阐明，可能涉及生物学、行为和社会等多项因素。本文对脑卒中后抑郁的发病机制以及诊断和治疗的最新进展进行综述。

Poststroke depression (PSD) is the most common emotional disorder after stroke. PSD is one of the factors affecting the quality of life of stroke patients, which can affect the recovery of daily living ability and nerve function impairment, and cause the protracted course of stroke. The pathophysiological mechanism of PSD has not been fully elucidated, and may involve biological, behavioral and social factors. This paper reviews the pathogenesis, diagnosis and treatment of PSD.