癫痫是一种中枢神经系统功能失常的慢性脑部疾病，其频繁发作给患者生活质量带来了严重影响。现阶段以西医抗癫痫药物治疗为主，但长期服用抗癫痫药物会引起一系列的不良反应。柴胡加龙骨牡蛎汤见于《伤寒论》第107条，古今医家常用来治疗“胸满烦惊”等精神情志疾病。近年来，许多研究表明该方在治疗癫痫方面具有显著疗效，柴胡加龙骨牡蛎汤能够通过调控神经递质、中枢神经细胞功能及炎症指标，从而发挥抗癫痫的目的。柴胡加龙骨牡蛎汤具有和解少阳、通阳泄浊和安神定志的作用。该方剂具有多靶点、多系统的抗癫痫效果。在癫痫患者的临床治疗中，柴胡加龙骨牡蛎汤发挥了重要的效用。本文从柴胡加龙骨牡蛎汤的方药配伍、治疗癫痫的相关作用机制、临床观察等方面对近年来该方治疗癫痫的基本情况进行综合概述。

Epilepsy is a chronic brain disease characterized by central nervous system dysfunction, and its frequent seizures have a serious impact on the quality of life for patients. At present, the primary treatment is based on Western anti-epileptic medications; however, long-term use of these drugs can lead to a series of adverse reactions. Chaihu Jia Longgu Muli Decoction, mentioned in Article 107 of the On Cold Damage (Shang Han Lun), has been commonly used by both ancient and modern physicians to treat mental and emotional diseases such as "chest fullness and agitation". In recent years, many studies have shown that this formula has a significant efficacy in treating epilepsy. Chaihu Jia Longgu Muli Decoction can exert its anti-epileptic effects by regulating neurotransmitters, enhancing the function of central nervous systems cells, and modulating inflammatory markers. This formula serves multiple functions, including harmonizing the Shaoyang, Tongyang Xiezhuo, and tranquilizing mind. Its effects are multi-targeted and systemic in nature. In the clinical treatment of patients with epilepsy, Chaihu Jia Longgu Muli Decoction has played an important role. This article offers a comprehensive overview of the recent developments regarding this formula's application in epilepsy treatment, focusing on the prescription compatibility, its underlying mechanisms of action, and relevant clinical observations.