脑卒中后抑郁（post-stroke depression，PSD）是脑卒中后最常见的神经精神并发症之一，发生率较高。抑郁状态抑制脑源性神经营养因子分泌，阻碍神经修复。早期识别和干预PSD对患者的功能康复、生活质量及预后至关重要。抗抑郁药可显著改善抑郁症状，早期使用抗抑郁药还可改善患者的运动功能和认知功能。在药物治疗的同时进行运动疗法和作业治疗，可增强药物治疗效果。PSD的早期干预可纠正患者对脑卒中后功能障碍的负性认知，减少抑郁复发风险，避免长期心理社会功能损害。

Post-stroke depression (PSD) is one of the most common neuropsychiatric complications following stroke, with a high incidence rate. Depressive states inhibit the secretion of brain-derived neurotrophic factors and hinder neural repair. Early identification and intervention of PSD are crucial for patients' functional recovery, quality of life, and prognosis. Antidepressants can significantly improve depressive symptoms, and early use of antidepressants can also improve patients' motor and cognitive functions. Combining pharmacotherapy with exercise therapy and occupational therapy can enhance the effectiveness of drug treatment. Early intervention for PSD can correct patients' negative cognition towards post-stroke dysfunction, reduce the risk of depressive relapse, and avoid long-term psychosocial impairment.