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聚焦前沿：血管性痴呆临床治疗与基础研究现状
Focusing on academic frontiers: Current status of clinical treatment and basic research of vascular dementia
血管性痴呆（vascular dementia，VaD）作为仅次于阿尔茨海默病的第二大常见痴呆类型，严重影响患者的生活质量。虽然VaD具有治疗可逆性，但是目前尚无特效治疗手段。中医药凭借疗效确切、不良反应少、治疗成本较低以及多靶点干预的独特优势被广泛用于VaD治疗，将其与现代医学治疗模式相结合可更好地服务于临床实践。本文从临床治疗和基础研究2个方面系统梳理了近10年来VaD领域的主要研究进展，包括当前VaD的主要临床治疗手段以及VaD中医药治疗在作用机制和潜在靶点上的探索成果，并结合当前科技进步趋势，对VaD未来研究和治疗发展方向作出思考与展望。
Vascular dementia (VaD), as the second most prevalent type of dementia after Alzheimer's disease, seriously affects the quality of life of patients. Although VaD is theoretically reversible, there is currently no definitive treatment available. Traditional Chinese Medicine (TCM) has been widely employed in VaD management due to its distinct advantages of proven efficacy, minimal adverse effects, cost-effectiveness, and multi-target intervention. The integration of TCM with modern medical approaches can better serve clinical practices. This article systematically reviews the main research advances in VaD over the past decade from both clinical treatment and basic research perspectives. It covers the current mainstream clinical interventions for VaD, along with exploratory findings regarding the mechanisms and potential targets of TCM in VaD treatment. Furthermore, considering the current trends in scientific and technological advancements, we provide insights and prospects on future research avenues and therapeutic development for VaD.
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