目的：报道1例喹硫平联合酒精中毒后出现横纹肌溶解合并周围神经损伤的患儿的临床特征和康复过程，结合文献复习，提高对喹硫平中毒的认识，并对合并周围神经损伤的患儿进行早期康复干预，以改善预后。

方法：详细描述1例因喹硫平联合酒精中毒导致横纹肌溶解合并周围神经损伤患儿的临床资料、肌电图及康复过程，并复习相关文献。

结果：患儿女性，14岁，因双下肢无力20 d为主诉就诊。患儿喹硫平联合酒精中毒后，出现双下肢肌力减退，无法站立和行走，肌电图提示双下肢周围神经损害。经过2周康复训练，患儿双下肢肌力、平衡功能及日常生活能力均有所改善。发病2个月时，患儿可在双杠内扶站30 min；发病1年后，可借助助行架在室内独立行走。

结论：虽然喹硫平中毒导致周围神经损伤的机制尚不明确，但早期积极康复治疗可改善患儿功能恢复。

Objective: To report the clinical characteristics and rehabilitation course of a patient who developed rhabdomyolysis with peripheral nerve injury following combined quetiapine and alcohol intoxication, and to review the literature to enhance understanding of quetiapine intoxication and emphasize the importance of early rehabilitation intervention in patients with concomitant peripheral nerve injury to improve prognosis.

Methods: The clinical characteristics, electromyography findings, and rehabilitation course of a patient who developed rhabdomyolysis with peripheral nerve injury following combined quetiapine and alcohol intoxication were described in detail, and the relevant literature was reviewed.

Results: A 14-year-old female was admitted with a 20-day history of bilateral lower limb weakness. Following quetiapine combined with alcohol intoxication, decreased muscle strength in both lower limbs developed, resulting in inability to stand or walk, and peripheral nerve damage in both lower limbs was indicated by electromyography. After two weeks of rehabilitation training, improvements were observed in the lower limb muscle strength, balance function, and activities of daily living. At two months after onset, the patient was able to stand with support between parallel bars for 30 min, and at one year, she was able to walk independently indoors with the aid of a walker.

Conclusion: Although the mechanism underlying peripheral neuropathy caused by quetiapine intoxication remains unclear, functional recovery can be improved by early and intensive rehabilitation.