本文系统阐述了清代医家邹澍论治癫痫的学术思想与方药特色。邹澍融贯《黄帝内经》《伤寒论》理论，创新提出“三逆、三亢、三窜”病机模型，用以阐释癫、狂、痫的病理机制及动态演变过程。“三逆（气逆、厥逆、神逆）”为病之根本，乃阴阳气血之深层逆乱；“三亢（阳亢、火亢、血亢）”为病之激化，属阳气火邪之亢盛状态；“三窜（风窜、痰窜、火窜）”为病之形征，系风痰火邪走窜经络、闭阻清窍之表现。基于此模型，邹澍提炼出“摄水火于土，摄阳归阴”的核心治法，强调以调和阴阳为本，而非单纯镇痉止搐。本文深入剖析了龙骨、牡蛎、防己和蝉蜕等药物的性味功效及其与病机的对应关系，并结合现代药理学研究，揭示了相关药物通过调节钙离子通道、抑制炎症反应以及抗神经元凋亡等多途径发挥抗癫痫作用。本研究凸显了邹澍注重病机辨析、强调整体调节的诊疗思想，为现代癫痫的中医药治疗提供了经典依据与临床思路。

This paper systematically explores the academic thought and characteristic formulas and medications of ancient physician ZOU Shu in Qing Dynasty for treating epilepsy. Integrating theories from the Huangdi Neijing and Shanghan Lun, Zou Shu innovatively proposed the "three reversals, three excesses and three escapes" pathogenesis model to elucidate the pathological mechanisms and dynamic evolution of mania, delirium and epilepsy. The "three reversals (Qi reversal, Jue reversal and Shen reversal)" represent the fundamental disease state, reflecting profound disturbances in Yin-Yang and Qi-blood. The "three excesses (Yang excess, fire excess and blood excess)" signify the intensified stage, characterized by hyperactive Yangqi and pathogenic fire. The "three scurries (wind scurry, phlegm scurry and fire scurry)" represent the manifest symptoms, reflecting the invasion of wind, phlegm and fire pathogens through the meridians and obstruction of the clear orifices. Based on this model, ZOU Shu distilled the core therapeutic principle of "regulating water and fire through earth, and guiding Yang back to Yin", emphasizing the fundamental importance of harmonizing Yin and Yang rather than merely suppressing spasms and convulsions. This paper provides an in-depth analysis of the properties, tastes and functions of medicinal herbs such as dragon bone, oyster shell, Stephania root and cicada slough, along with their corresponding relationships to the pathogenesis. Integrating modern pharmacological research, it reveals that these herbs exert antiepileptic effects through multiple pathways, including regulating calcium ion channels, inhibiting inflammatory responses, and preventing neuronal apoptosis. This paper highlights ZOU Shu's diagnostic philosophy, which prioritizes disease mechanism analysis and holistic regulation, providing classical foundations and clinical insights for modern traditional Chinese medicine treatment of epilepsy.